As stem cells are the source of all tissues, understanding their properties helps in our understanding of the healthy and diseased body's development and homeostasis. Research 20 September Research 20 September Open Access. Research 18 September Research 16 September Research 10 September Open Access.
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Search My Account Login. Atom RSS Feed Stem-cell research Definition Stem-cell research is the area of research that studies the properties of stem cells and their potential use in medicine. Moiseev , Elena V.
California’s stem cell research fund dries up | Science | AAAS
Babenko , Olga S. Epifanovskaya , Vladislav S.
Sergeev , Anna A. Dotcenko , Evgeny A. Bakin , Elena A. Other cancers, such as head and neck cancers, are often resistant to current therapies, making less-invasive treatments more difficult.
In addition, current chemotherapies cause severe side effects because they target all rapidly dividing cells. Treatments that target only cancer stem cells would cause fewer side effects for patients. Cancer stem cells were first identified in leukemia. U-M researchers discovered the first cancer stem cells in solid tumors, finding them in breast cancer. Since then, cancer stem cells have been identified in brain, colon, head and neck, pancreas and central nervous system tumors.
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Work is ongoing to identify stem cells in other tumor types. Researchers take samples of tumors removed from patients during surgery, always with the patient's informed consent. The cells within the tumor are then sorted based on their expression of certain cell markers on their surface. Sorted cells can be injected into mice, which are then watched for new tumor growth. When only specific sorted cells form new tumors, researchers then test those cells for properties of stem cells.
The next step is to understand how cancer stem cells work and identify drugs that will kill the stem cells without harming normal cells. The work on cancer stem cells is still in early stages, primarily taking place in the laboratory and early clinical trials. U-M is conducting clinical trials of experimental therapies targeted at cancer stem cells in multiple myeloma, pancreatic cancer and breast cancer. Initial results are positive, but additional trials in a larger number of patients will be necessary. If these new drugs are proven to be safe and effective, they could become the first approved cancer treatments to be developed as a result of cancer stem cell research.
Cancer Stem Cell Research Cancer stem cells are the small number of cells within a tumor that drive the tumor's growth. These cells have three characteristics in common: 1. Adult stem cells can renew themselves through cell division for long periods of time. Is this the same as embryonic stem cells? Why is research on cancer stem cells important? Recent reports show cancer deaths are decreasing, so aren't we doing a good job already of killing cancer?
In what tumor types have cancer stem cells been identified? How are cancer stem cells identified?
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