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Purinergic (P2Y) Receptors
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Extracellular purines, purinergic receptors and tumor growth | Oncogene
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Learn more. The aim of this study was to characterize P2 receptors in the arterial vascular bed of human perfused placental cotyledons. ATP 0. A smooth muscle P2 receptor mediates vasoconstriction to UTP, and may indicate a further subtype.
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These families have been further subdivided according to the distinct structure of mammalian receptors. The P2X receptor family comprises subtypes P2X 1—6. From the vascular perspective P2X 1 previously known as P 2X is the most relevant, being found in smooth muscle. However, it is also active at P2X 1 receptors.
This study characterizes the P2 receptors mediating responses to purine and pyrimidine nucleotides in the arterial bed of human placental cotyledons. Read and colleagues described P2X and P2Y receptors in human placental cotyledons, but did not examine the effects of pyrimidines. A preliminary account of our results has been presented at the Purines Meeting Ralevic et al. Placentae were obtained from 16 healthy women 20—43 years undergoing elective Caesarean section with epidural anaesthesia.
None of the women had received any drug treatment known to have chronic vascular effects. Two or three placental cotyledons were isolated from each placenta. Cotyledons were cut away from the surrounding tissue and removed for perfusion. The perfusate was Krebs solution pH 7. Preparations were allowed to equilibrate for 20 min before experimentation. Preparations not achieving a stable perfusion pressure of less than 50 mmHg were discarded.
Pharmacology of Purine and Pyrimidine Receptors
Vertical lines show s. Removal of the endothelium produced a significant increase in basal tone of the preparations of There was no significant difference between the mean responses. The pD 2 value for ATP, 8. After each of these treatments the ability of the smooth muscle to relax was unimpaired, as evidenced by responses to the direct smooth muscle relaxing agent SNP 0. Representative trace showing vasodilator responses decrease in perfusion pressure, mmHg of a single human placental cotyledon to purine and pyrimidine nucleotides and to sodium nitroprusside SNP; Doses are given as —log mol.
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