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Cytochrome P450_ Structure Mechanism and Biochemistry 2005
Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P enzymes, with a discussion of the structures of P enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P inhibition. Two more chapters discuss the nature and roles of cytochrome P enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P enzymes in biotechnology.
Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P to its relevance in human medicine.
Cytochrome p structure mechanism and biochemistry pdf download
Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years. Product details Format Paperback pages Dimensions x x Paul Ortiz de Montellano has brought together a group of new authors as well as authors from previous editions to produce a timely volume that will be of considerable interest to a broad array of P researchers.
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The explosion of discovery of CYP cytochrome P genes through genome analysis--more than to date--provides the more than 10, scientists around the world who study these monooxygenases a rich source of interesting and important research problems. Many have remained central elements over the 18 years that span the three editions of this book, including mechanisms of catalysis, oxygen activation and inhibition, gene regulation, and P structure.
Each new edition updates our knowledge of such central issues in the study of Ps, emphasizing the timeliness of this newest volume.
In this newest edition, we find that the newest discussion of P structure includes information of bacterial soluble Ps interwoven with that of eukaryotic membrane bound of this superfamily, highlighting the newest developments in this area. The complete battery of human Ps is now known and summarized in the new edition.
In addition, general overviews of plant Ps and those from microbes contained within this newest edition provide a broader view of P diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying Ps. The third edition of Cytochrome P Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P research while at the same time learn of new directions in the field. It is an excellent and most useful volume. Michael R. Waterman, Ph.
The sequences of several thousand Ps are now known, and recent progress in understanding the properties and functions of those in the microbial and plant worlds, as well as the better known mammalian isozymes, is now included. In keeping with this interest, cytochrome P has since its discovery in the s been the subject of several books, numerous review articles, and countless conferences. The edition of Cytochrome P Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject.
Hoping that lightning will strike twice, Ortiz de Montellano has now produced a second edition with 15 new chapters.
In my estimation, he has again succeeded in bringing the P field into sharp focus. The new edition is divided into four sections. The opening section contains a chapter each on two types of model systems often used to study P Groves and Han provide a thorough discussion of functional metalloporphyrin model systems, and Marnett and Kennedy review how studies of peroxidases can provide insight into the mechanism of P
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