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Macrophages and other scavenger cells then engulf the membrane packets and process them for reuse as the most basic cellular components. In some instances, neighbouring cells may also engulf the degraded components. Employing the intrinsic pathway , cancer cells, cells that are infected with bacteria or virus particles, and mutant cells can be assigned to apoptosis.

Definition of apoptosis - NCI Dictionary of Cancer Terms - National Cancer Institute

The extrinsic pathway is commonly associated with cellular death receptors. Manipulating apoptosis is one avenue through which scientists can address a number of vexing medical problems.


Cancer requires the suppression of apoptosis to allow survival of the abnormal tumour cells. Restoring effective surveillance of abnormal cells can contribute dramatically to cancer eradication. Likewise, enhanced targeting of infected cells for apoptotic destruction mimics the physiological role of apoptosis in resolving infection by disposing of the infected cells. Inhibition of apoptosis has the potential to dramatically limit the damage resulting from episodes of ischemia in cardiac and neural tissue ischemia is a reduction in blood flow to affected tissues.

These opportunities and a basic curiosity about how cells regulate their own mortality sustain an extensive research effort centring around the mechanisms controlling and executing apoptosis.

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Apoptosis/ Necrosis Assay Kit (blue, green, red) (ab176749)

Submit Feedback. Thank you for your feedback. Introduction Discovery of programmed cell death Regulation of apoptosis Apoptosis in medicine. Written By: Paul H. See Article History. Alternative Titles: programmed cell death, programmed death, programmed life termination. Read More on This Topic. Many cells undergo programmed cell death, or apoptosis, during fetal development. Apoptosis also may occur when a cell…. Start Your Free Trial Today. Learn More in these related Britannica articles:.

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Apoptosis also may occur when a cell becomes damaged or deregulated, as is the case during tumour development and other pathological processes. Thus, when functioning properly, the body can induce…. It is known that both chemotherapy and radiation therapy kill cells by inducing apoptosis, essentially making the cell trigger the program of cell death rather than succumb to the action of the chemical itself. Another mechanism of…. Programmed cell death plays an important role in vertebrate ontogeny embryological development and teratogenesis the production of malformations , as well as in the spectacular metamorphoses that affect tadpoles or caterpillars.

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