This multi-authored volume provides a historical, biochemical, and chemical rationale to the search for plant, marine, or microbial sources that may provide future templates for drug lead optimization and synthetic drug design. Grouped by source organism, each chapter includes the history of the drug and a discussion of its mechanism in action, medicinal chemistry, and biochemistry. The authors characterize each compound by its structure, genetics, molecular biology, synthesis, and possible derivatives.
The final chapter covers drug candidates that are in preclinical or clinical development and may be used in the future. Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientists engaged in developing new and improved drugs based on natural sources.
Review The book brings home to us not only the amazing chemical complexity of the natural world but also the vast reservoir of potential new healing agents that yet remain to be tapped. This impressive work, which maintains a uniformly high standard throughout, will be of major benefit to a wide readership…. It seems likely that it will remain the definitive work in its genre for many years to come. Understanding the science behind the claims will help in the production and marketing of teas and tea products.
Emphasizing black and green teas equally, the book presents comprehensive and up-to-date reviews and perspectives on the chemistry of tea components and the molecular biology of green tea catechins and black tea theaflavins. It covers the analysis, formation mechanisms, and bioavailability of tea polyphenols and discusses bioactivities of teas including anticancer, anti-inflammatory, anti-obesity, and anti diabetes.
Increased awareness of the many health benefits of tea has fueled an increase in the market for ready to drink teas and tea products in general that will continue to grow. This expanding market requires a resource that provides the evidence. The editors of this volume have more than research publications in tea, and experience in editing more than 50 books between them. Under their expertise and editorial guidance, the contributors present chapters that explore the science behind the health claims of teas.
An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers.
The book is also excellent for upper division or post-graduate courses. Experts from around the world examine a multitude of topics, including evaluation of extracts from tropical plants for potential anticancer activity and cancer chemopreventive activity; use of Chinese lacquer tree sap products as pharmaceutical intermediates; and new approaches to drug discovery from the rainforest.
Review …its chapters are well referenced…index covers the compounds presented in each chapter…Pharmacy schools that have active natural products programs should purchase this book for its library…faculty, post-doctral fellows and senior graduate students should consider it for personal purchase. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins.
Far-reaching in its scope, this text is a baseline reference that students and researchers in a broad range of fields such as medicine, plant science, biotechnology, crop science, natural products chemistry, and engineering will consult regularly. It will also serve as a useful tool for individuals and companies seeking to invest in this dynamic area. Review "This book serves as an excellent introduction to biopharmaceuticals and as a source of references for those wanting more details. Caffeine answers questions for a broad range of readers interested in the effects beverages and foods containing this dietary methylxanthine have on human health, nutrition, and physiological functioning.
The composition, processing, consumption, health effects, and epidemiological correlations of caffeine are examined in detail. It is often said that too much caffeine is "bad for you. Get the facts on consumption of caffeine-containing products with this authoritative text. Chapters 1 and 2 offer an introductory, concise overview of the chemistry and analysis of methylxanthines. Consumption of caffeine is also examined in detail in Chapter 9. Chapter 10 provides an easy-to-read overview of the basic physiology and biochemistry of caffeine.
The ergogenic, cognitive, and emotional effects of caffeine are discussed in Chapters 11 and Chapters 13 through 16 deal with specific health effects-serum cholesterol, cancer and fibrocystic breast disease, calcium and bone health, and human reproduction. For physicians, nutritionists, other health professionals, food scientists, and everyone interested in the effects of caffeine on the human body, Caffeine is a convenient, single-source reference.
However, despite the massive scientific literature on this important substance, most reviews have either focused on limited areas of study or been produced in popular form by individuals with surprisingly little relevant scientific background. Caffeine and Activation Theory: Effects on Health and Behavior brings together the leading experts from seven different countries to provide researchers and clinicians with the most comprehensive and balanced review of the scientific literature on the effects of caffeine found anywhere.
It devotes unprecedented coverage to the impact of caffeine on cardiovascular functioning and pathology, details the pharmacological properties and neurophysiological effects of the drug, and thoroughly reviews literature concerned with the role of this powerful stimulant in mood, task performance, and psychopathology. This important new book is also the first source to provide an integrative scientific treatment of the effects of caffeine consumption on menstrual endocrinology and pathology, as well as on reproduction.
Rounding out the coverage is a thorough review of emerging research on the possible benefits of caffeine and catechins in green and black teas. The highly integrative final chapter provides a clear understanding of what is known about the effects of caffeine, identifies specific areas in which further research is needed, and provides important methodological guidelines that promise to optimize future research endeavors.
Filling the need for a current comprehensive resource, this volume provides extensive reviews of the major bodies of literature on caffeine, stimulates and guides future research, and provides clinicians with the information they need to understand, diagnose, and treat the effects of caffeine consumption in their patients.
Research shows that these biopolymers can be used to combat various infectious as well as inflammatory, oxidative, and carcinogenic factors. This book is an important resource for those leading this effort. When the "Father of Medicine" uttered those famous words, spices were as important for medicine, embalming, preserving food, and masking bad odors as they were for more mundane culinary matters. Author James A. Duke predicts that spices such as capsicum, cinnamon, garlic, ginger, onion, and turmeric will assume relatively more medicinal importance again, as the economic costs and knowledge of the side-effects of prescription pharmaceuticals increase.
After all, each spice contains thousands of useful phytochemicals. Pharmaceuticals usually contain only one or two. Discover the Science behind the Folklore Spices are important medicines that have withstood the empirical tests of millennia. Nearly 5, years ago Charak, the father of Ayurvedic medicine, claimed that garlic lightens the blood, reduces tumors, and is an aphrodisiac tonic.
Today scientists say it thins the blood, prevents cancer, and increases libido. For centuries people worldwide have used spices to cure a myriad of ailments and to preserve foods. Now science is proving that these spices may preserve us with their antioxidant and antiseptic activities. For each spice, it lists: Scientific name Common name Medicinal activities and indications Multiple activities Other uses, especially culinary Cultivation Chemistry Important phytochemical constituents and their activities The handbook also includes market and import data, culinary uses, ecology and cultural information, and discusses at length the use of spices as antiseptics and antioxidants.
In the second edition, world-renowned ethnobotanist James A. The book contains more species, phytochemicals, proven indications, folk indications, and dosage data than the first edition in a new easier to use format. The in-depth content, the addition of color plates and over black and white illustrations makes this book the most comprehensive resource on medicinal herbs available.
The entries are now arranged alphabetically by common name with the scientific name in parenthesis. Major synonyms are also provided. The debate continues on how these plants work and how they should be used. The book codifies the vast technical and culinary knowledge for the many professionals who develop and market foods. While many reference books on spices include alphabetized descriptions, the similarity between this book and others ends there.
The author includes a description of spice properties, both chemical and sensory, and the culinary information that will aid in product development. New to this edition is coverage of spice labeling and a chapter on commercial seasoning formulas. It explores how these ingredients are commonly used with spices to create authentic or new flavors. The author has created a complete reference book that includes traditionally popular spices and flavorings as well as those that are emerging in the US to create authentic or fusion products. In a single volume, this bookoffers a thorough inventory of the various types of plant-derived compounds.
It covers their chemical composition, structure, and properties alongside the most effective ways to identify, extract, analyze, and characterize new plant-derived compounds. The authors examine new information on the chemical mechanisms plants use to deter predators and pathogens, attract symbiotic organisms, and defend themselves against environmental stress—insights which are key for adapting such mechanisms to human health. The book incorporates in-depth treatment of natural product biosynthesis with new collection and extraction protocols, advanced separation and analytical techniques, up-to-date bioassays, as well as modern molecular biology and plant biotechnology for the production of natural products.
Review Praise for the First Edition: The five authors all have a common background in the natural sciences but their professional careers have taken them to diverse positions inside or outside of academia…and this diversity is definitely one of the strongest aspects of the book. Review "I strongly recommend this book. A superb writer and expert, James A.
The idea of choosing species of medicinal plants from the Bible is original and intriguing. The choice is special and in view of its originality, it is excellent. Attention is turned to not only medical but also historical and cultural aspects of using plants. The book is elegantly bound and edited, with many illustrations in colour and with great meticulousness it collects data concerning common names very numerous , activities, indications, downsides or dosages.
Many species are widespread in warm or tropical semi-arid regions, yet the distribution of others is limited to a few living in desert or wet mountainous regions. While some species have been adopted as medicinal plants since ancient times and others are used locally in folk medicine, scientists have yet to discover the full biological activity of the many aloe compounds. In order to realize the vast potential of the genus, it is essential to gather the knowledge acquired over the last fifty years into one comprehensive compilation.
A landmark publication, Aloes: The genus Aloes reviews all botanical, chemical, biochemical, and medical information as well as commercial applications of aloes. The first part of the book features information on the habitat and taxonomy of aloes, followed by a section on aloe constituents. Part 3 focuses on therapeutic activity and includes chapters on aloe's role in wound healing, skin cancer, and the immune system.
The final section is devoted to aloe biology. Chapters are written by accomplished contributors who share their expertise and insight from all areas of academia and industry. Providing a solid foundation for future research, this volume brings together a wealth of information on aloes from a variety of sources, including seldom-recorded folk customs. It is a valuable guide for researchers and professionals in the areas of botany, natural product chemistry, pharmacology, dermatology, and immunology.
Review [T]he book presents a useful survey of the medicinal aspects of aloes and our scientific understanding of the efficacy of Aloe products and treatments. He has been working on the aloe leaf exudate compounds since and has also, with collaborators produced two comprehensive literature surveys of the leaf parenchyma gel.
Aloes : the genus aloe / edited by Tom Reynolds. - Version details - Trove
The extensive collections of aloes at Kew have given him a unique insight into the science of the genus. Following a comprehensive introduction to the genus, the book discusses the botanical, phytochemical and biological aspects of a number of important species of Artemisis. Considering that the discovery of artemisinin, a highly active antimalarial agent from the Chinese herb A. This volume includes chapters on all aspects of the crops' botany; crop improvement, agronomy, chemistry, post-harvest technology, processing, diseases, insect pests, marketing, economy and uses.
All the available information has been collected and presented by experts for the use of students, teachers and research workers in the field, and will remain the major reference source for all pepper workers for some time to come. The Western Ghat forest of the Malabar coast, India, is the center of origin and diversity for cardamom and it might have been nature's design that the King and Queen of spices black pepper and cardamom originated in the same forest.
This volume contains sixteen chapters, fourteen on cardamom and one each on large cardamom and false cardamoms. All aspects of the cardamom crop have been covered in this volume, and each chapter is written by experts in their respective fields. Principal coordinate analysis was also performedand the ordination displayed in two dimensions. Both the marker systems being employed to assess the genetic diversity in Aloe vera accessions were quite informative and were able to generate adequate polymorphism Fig. A total of bands were amplified, of which were observed to be polymorphic resulting in a polymorphism frequency of The molecular size of the bands varied between bp and several accession specific bands have been identified Fig.
The extent of polymorphism per primer ranged from with ten alleles per primer OPA-9 0. ISSR analysis: Of the 25 ISSR primers screened, 24 primers produced amplification products, of which 19 primers revealed polymorphic loci across the Aloe vera accessions tested. A total of bands were amplified of which 85 amplicons were observed to be polymorphic resulting in polymorphism of The average number of polymorphic amplicons per primer was 4. The number of bands amplified per primer varied between 2 UBC primer No.
The size of the amplicons varied between bp and several accession specific bands have been identified as in Fig. The extent of polymorphism varied with ten alleles between UBC 0. Similarity matrix values based on ISSR markers ranged from 0. Clustering of accessions based on dendrogram and PCO analysis was similar for most accessions except for the accessions IC which is separately sub-grouped in cluster II.
Although the two marker systems sampled different segments of the genome, the clustering pattern of the genotypes was almost similar with both the marker systems and most of the accessions were placed in their respective clusters with minor changes. The second cluster II further divided into 2 sub-clusters. The accession IC and IC appeared to be closer to each other with a similarity coefficient of 0. Principal Coordinate Analysis PCO based on genetic similarity showed the relationship among accessions in two dimensional spaces.
An understanding of the extent of genetic diversity is important for both plant breeding and germplasm collection. In Aloe vera traditional methods like horticultural traits are relatively less reliable and inefficient for precise discrimination of closely related genotypes Nejatzadeh-Barandozi et al.
Hence, selection based on genetic information using neutral molecular markers is essential as it is more reliable and consistent. Among different marker systems available, RAPD and ISSR markers became popular in diversity studies because of simplicity, rapid, inexpensive and applicable to any genome without any prior information regarding the genome of the plant. The RAPD primers revealed The RAPD markers cover the entire genome in coding and non coding regions including repeated or single-copy sequences, while ISSR markers disclose polymorphism from sequences between two microsatellite primer sites Williams et al.
Both the marker techniques provides a useful approach for evaluating genetic differentiation, significantly in those species that are poorly known genetically and are propagated vegetatively like monocot genus in Musa Bhat and Jarret, and Lilium Haruki et al. Recently, AFLP based characterization of Aloe vera accessions from different location of Madhya Pradesh, India has reported modest level of genetic variability Tripathi et al.
This low level of variability could be because of small sample size collected from the limited geographical regions. Similarly, Darokar et al. Nayanakantha et al. This variability can be used for genetic improvement through breeding programs and the accession specific bands were identified in this study will provide tags for future genetic improvement as well as in authenticating the genotypes.
The authors profusely thank Department of Genetics and Biotechnology, Osmania University, Hyderabad, India, for funding the research work. Germplasm was arranged by Dr. Subscribe Today. Science Alert. Arrows indicates the accession specific bands. All Rights Reserved.
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Research Article. Basha and Roja Rani Anupalli. Similar Articles in this Journal. Search in Google Scholar. Basha and Roja Rani Anupalli, International Journal of Pharmacology, DOI: Table Details of Aloe vera accessions used in diversity analysis. Bhaludra, C. Bethapudi, A. Murugulla, C. Pullagummi and T. Latha et al.
Cultivation, phytochemical studies, biological activities and medicinal uses of Aloe ferox , Grandfather of Aloes an important amazing medicinal plant. Jarret, Crop Evol. Beland, An evaluation of the biological and toxicological properties of Aloe barbadensis Miller , Aloe vera. Health Part C: Environ. Vanderberg and T. Warkentin, Cultivar identification and genetic relationship among selected breeding lines and cultivars in chickpea Cicer arietinum L. Euphytica, Rai, A. Gupta, A. Shasany, S.
Rajkumar, V. Sundaresan and S.
Khanuja, Molecular assessment of germplasm diversity in Aloe spp. Plant Sci. Doyle, J. Doyle, Isolation of plant DNA from fresh tissue.
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